David A. D’Alessio

David A. D’Alessio’s indexed work centers on the physiology of proglucagon-derived peptides, particularly glucagon and GLP-1, in health and disease, a theme his most-cited senior-author review develops in depth. Related senior-author studies examine central control of body weight and appetite and report that ghrelin suppresses glucose-stimulated insulin secretion and worsens glucose tolerance in healthy humans, linking gut and brain signals to islet function. His earlier first-author work showed that GLP-1 enhances glucose tolerance both by stimulating insulin release and by increasing insulin-independent glucose disposal, a mechanistic claim that has shaped subsequent incretin research. Beyond these, D’Alessio contributed as a middle author to the ADA/EASD consensus reports on management of hyperglycemia in type 2 diabetes, and to a review of GLP-1 biology co-authored with Daniel J. Drucker