A. S. Slutsky

A. S. Slutsky's indexed work centers on the mechanisms by which mechanical ventilation itself injures the lung. An early first-author paper asked whether mechanical ventilation contributes to multiple system organ failure, a question that shaped later investigations into ventilator-induced injury. As senior author, Slutsky showed that mechanical ventilation alters local and systemic cytokine release in an animal model of acute respiratory distress syndrome, and characterized impaired lung and chest wall mechanics in ARDS patients. Earlier work modeled the factors inducing periodic breathing in humans, reflecting a career-long interest in respiratory physiology. Later contributions extend this line into consensus and translational territory. Slutsky was a middle author on the ESICM guidelines on ARDS definition, phenotyping and respiratory support strategies, and on extracorporeal life support for adults with ARDS, the latter alongside Daniel Brodie