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Aashish Manglik’s indexed work centers on the structural biology and signaling mechanisms of G protein–coupled receptors (GPCRs), with a particular emphasis on opioid and sensory receptors. His early first-author contribution to the crystal structure of the µ-opioid receptor bound to a morphinan antagonist (2012, cited over 1,300 times) provided a foundational view of how opioid drugs engage their target. As senior author, he later solved the structure of hepcidin-bound ferroportin (2020, cited over 340 times), revealing the molecular basis of iron homeostasis, and led the structural determination of a human odorant receptor recognizing an odorant (2023, cited over 230 times), expanding GPCR structural knowledge into chemosensation. His first-author review on nanobodies for studying GPCR structure and function (2016, cited over 270 times) has become a methodological reference in the field. Beyond his lead-author portfolio, Manglik contributed as a middle author to several high-impact structural studies, including the activation mechanism of the µ-opioid receptor (2015, Nature, cited over 900 times) and the structure of the µ-opioid receptor–Gi protein complex (2018, Nature, cited nearly 700 times), which together clarified how opioids signal through G proteins. He also participated in a yeast surface display platform for discovering conformationally selective nanobodies (2018, Nature Structural & Molecular Biology, cited over 590 times), a tool he has applied in his own work. Across these contributions, Manglik’s research consistently combines high-resolution structural determination with mechanistic insight, advancing understanding of how GPCRs and related membrane proteins recognize ligands, undergo conformational changes, and drive physiological responses.
David E Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S Jureka, Kirsten Obernier, Jeffrey Z Guo, Jyoti Batra, Robyn M Kaake, Andrew R Weckstein, Tristan W Owens, Meghna Gupta, Sergei Pourmal, Erron W Titus, Merve Cakir, Margaret Soucheray, Michael McGregor, Zeynep Cakir, Gwendolyn Jang, Matthew J O'Meara, Tia A Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L Swaney, Jacqueline M Fabius
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Conor McMahon, Alexander S Baier, Roberta Pascolutti, Marcin Wegrecki, Sanduo Zheng, Janice X Ong, Sarah C Erlandson, Daniel Hilger, Søren G F Rasmussen, Aaron M Ring, Aashish Manglik, Andrew C Kruse
Michael Schoof, Bryan Faust, Reuben A Saunders, Smriti Sangwan, Veronica Rezelj, Nick Hoppe, Morgane Boone, Christian B Billesbølle, Cristina Puchades, Caleigh M Azumaya, Huong T Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Sasha Dickinson, Henry C Nguyen, Cynthia M Chio, Gregory E Merz, Michael C Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya A Anand, Niv Dobzinski, Beth Shoshana Zha, Camille R Simoneau, Kristoffer Leon, Kris M White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M Smith, Alexandrea N Rizo, Frank Moss, Axel F Brilot, Sergei Pourmal, Raphael Trenker, Thomas Pospiech, Sayan Gupta, Benjamin Barsi-Rhyne, Vladislav Belyy, Andrew W Barile-Hill, Silke Nock, Yuwei Liu, Nevan J Krogan, Corie Y Ralston, Danielle L Swaney, Adolfo García-Sastre, Melanie Ott, Marco Vignuzzi, QCRG Structural Biology Consortium, Peter Walter, Aashish Manglik
Jung-Eun Shin, Adam J Riesselman, Aaron W Kollasch, Conor McMahon, Elana Simon, Chris Sander, Aashish Manglik, Andrew C Kruse, Debora S Marks
Christian B Billesbølle, Caleigh M Azumaya, Rachael C Kretsch, Alexander S Powers, Shane Gonen, Simon Schneider, Tara Arvedson, Ron O Dror, Yifan Cheng, Aashish Manglik