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Alexander E. Gorbalenya’s indexed work centers on the molecular evolution, classification, and functional genomics of RNA viruses, particularly coronaviruses. He led the effort to formally classify the novel coronavirus as Severe acute respiratory syndrome-related coronavirus and name it SARS-CoV-2 in 2020, a paper that has garnered over 7,700 citations and shaped global pandemic response. Earlier foundational contributions include defining the unique genomic and proteomic features of SARS-coronavirus (2003, over 1,200 citations), and pioneering sequence-based analyses that identified two superfamilies of putative helicases (1989) and NTP-binding domains in viral proteins (1989–1990), each with hundreds of citations. His work on Nidovirales as evolving the largest RNA virus genomes (2006) further established his role in characterizing this viral order. Beyond his lead-author works, Gorbalenya contributed to the International Committee on Taxonomy of Viruses’ ratified taxonomic changes (2018, over 1,000 citations) and co-authored a comprehensive review of virus-encoded proteinases in Nidovirales (2000, over 1,000 citations). He also participated in the genomic characterization of a novel coronavirus associated with acute respiratory distress syndrome (2012, over 900 citations). Across these contributions, his career reflects a sustained focus on using comparative sequence analysis to reveal conserved functional domains and evolutionary relationships among positive-strand RNA viruses, directly informing both fundamental virology and outbreak response.
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, Haagmans BL, Lauber C, Leontovich AM, Neuman BW, Penzar D, Perlman S, Poon LL, Samborskiy D
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Eric J Snijder, Peter J Bredenbeek, Jessika C Dobbe, Volker Thiel, John Ziebuhr, Leo L M Poon, Yi Guan, Mikhail Rozanov, Willy J M Spaan, Alexander E Gorbalenya
Andrew M Q King, Elliot J Lefkowitz, Arcady R Mushegian, Michael J Adams, Bas E Dutilh, Alexander E Gorbalenya, Balázs Harrach, Robert L Harrison, Sandra Junglen, Nick J Knowles, Andrew M Kropinski, Mart Krupovic, Jens H Kuhn, Max L Nibert, Luisa Rubino, Sead Sabanadzovic, Hélène Sanfaçon, Stuart G Siddell, Peter Simmonds, Arvind Varsani, Francisco Murilo Zerbini, Andrew J Davison
A E Gorbalenya, E V Koonin, A P Donchenko, V M Blinov