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Alexander S. Hauser's indexed work centers on the pharmacology and pharmacogenomics of G protein-coupled receptors (GPCRs). His most-cited first-author study, a 2017 review in *Nature Reviews Drug Discovery* (2738 citations), established a comprehensive view of trends in GPCR drug discovery, cataloging new agents, targets, and therapeutic indications. He further explored the genetic basis of drug response in a 2017 *Cell* paper (658 citations) on pharmacogenomics of GPCR drug targets, and later extended this analysis to the structural level in a 2021 *Nature Structural & Molecular Biology* study (316 citations) that examined GPCR activation mechanisms across classes and scales. Beyond his lead-author work, Hauser contributed to foundational resources and collaborative discoveries. He was a middle author on the 2017 *Nature* paper detailing selectivity determinants of GPCR–G-protein binding (408 citations) and on the 2019 *Cell* study describing the pairing of peptides to GPCRs to discover human signaling systems (264 citations). As senior author, he developed PGxDB, an interactive web-platform for pharmacogenomics research, and investigated differential G protein activation by dopamine D2 receptor isoforms. Together, these contributions map a sustained effort to integrate structural, genomic, and computational approaches to understand GPCR signaling and its therapeutic modulation.
Alexander S Hauser, Misty M Attwood, Mathias Rask-Andersen, Helgi B Schiöth, David E Gloriam
Alexander S Hauser, Sreenivas Chavali, Ikuo Masuho, Leonie J Jahn, Kirill A Martemyanov, David E Gloriam, M Madan Babu
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Gáspár Pándy-Szekeres, Christian Munk, Tsonko M Tsonkov, Stefan Mordalski, Kasper Harpsøe, Alexander S Hauser, Andrzej J Bojarski, David E Gloriam
Tilman Flock, Alexander S Hauser, Nadia Lund, David E Gloriam, Santhanam Balaji, M Madan Babu
Alexander S Hauser, Albert J Kooistra, Christian Munk, Franziska M Heydenreich, Dmitry B Veprintsev, Michel Bouvier, M Madan Babu, David E Gloriam