Aparna Bhaduri

Aparna Bhaduri studies how the developing human cortex builds its diverse cell types, and how those programs go wrong in cancer. Her most-cited lead-author work uses cortical organoids to show that cell stress impairs molecular subtype specification, a caution for disease modeling, while a companion study maps cortical arealization and its dynamic molecular signatures across the developing brain. She has also applied single-cell approaches to glioblastoma, identifying outer radial glia-like cancer stem cells as a source of tumor heterogeneity, work that has drawn over 400 citations. Beyond these, she contributed to consortium-scale efforts, including single-cell genomic identification of cell type-specific molecular changes in autism and spatiotemporal gene expression trajectories of human cortical developmental hierarchies, both with Arnold R. Kriegstein