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Gary Ruvkun’s indexed work centers on the genetic and molecular mechanisms that control developmental timing and longevity in *Caenorhabditis elegans*. As senior author on a series of landmark studies, he identified **the 21-nucleotide *let-7* RNA as a regulator of developmental timing and demonstrated its conservation across animal phyla, a finding that helped establish the microRNA field. His earlier work on the *lin-4* RNA’s posttranscriptional regulation of *lin-14* provided the first mechanistic understanding of how small RNAs control temporal pattern formation. Ruvkun also led the discovery that the insulin/IGF-1 receptor homolog DAF-2** and its downstream transcription factor DAF-16 form a conserved signaling pathway that regulates lifespan and diapause, with the *daf-2* paper accumulating over 2,200 citations. Beyond his lead-author contributions, Ruvkun contributed to a uniform system for microRNA annotation that standardized nomenclature across the field. He also participated in studies linking RNA interference machinery to the expression of small temporal RNAs that control *C. elegans* developmental timing. Earlier in his career, he performed **transposon Tn5 mutagenesis in *Rhizobium meliloti*** to characterize symbiotic and auxotrophic mutants. Across these works, Ruvkun’s research has consistently uncovered fundamental regulatory logic—from small-RNA-mediated developmental control to insulin-signaling pathways that govern aging—using *C. elegans* as a model system.
Nicolas J Lehrbach, Gary Ruvkun
Nicolas J Lehrbach, Gary Ruvkun
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Kurt Warnhoff, Gary Ruvkun
Kai Mao, Peter Breen, Gary Ruvkun
Kai Mao, Peter Breen, Gary Ruvkun