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Han Liang’s research focus centers on the systematic characterization of molecular alterations across diverse tumor types, with a particular emphasis on functional genomics and non-coding RNA. Publicly indexed outputs suggest a significant interest in the genomic landscape and clinical relevance of A-to-I RNA editing, a topic explored in a 2015 study with over 580 citations. Liang has also led the development of major bioinformatics resources, including TCPA, a platform for cancer functional proteomics data, and TANRIC, which facilitates the exploration of long non-coding RNAs. These efforts often aim to bridge the gap between high-throughput sequencing and clinical utility, as seen in work assessing the predictive power of genomic and proteomic data across various cancers. Beyond primary research, Liang has contributed to large-scale consortia, including middle-author roles in integrated genomic characterizations of endometrial carcinoma and the development of the TCGA Pan-Cancer Clinical Data Resource. These collaborative efforts involve mapping oncogenic signaling pathways and identifying stemness features associated with tumor dedifferentiation. Liang’s portfolio also includes specific investigations into molecular differences in cancer between male and female patients, highlighting a commitment to precision medicine. Collectively, these works demonstrate a consistent trajectory of building open-access platforms and analytical frameworks to decode the complex regulatory mechanisms driving human malignancies.
Cancer Genome Atlas Research Network, Cyriac Kandoth, Nikolaus Schultz, Andrew D Cherniack, Rehan Akbani, Yuexin Liu, Hui Shen, A Gordon Robertson, Itai Pashtan, Ronglai Shen, Christopher C Benz, Christina Yau, Peter W Laird, Li Ding, Wei Zhang, Gordon B Mills, Raju Kucherlapati, Elaine R Mardis, Douglas A Levine
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Jongchan Kim, Hai-Long Piao, Beom-Jun Kim, Fan Yao, Zhenbo Han, Yumeng Wang, Zhenna Xiao, Ashley N Siverly, Sarah E Lawhon, Baochau N Ton, Hyemin Lee, Zhicheng Zhou, Boyi Gan, Shinichi Nakagawa, Matthew J Ellis, Han Liang, Mien-Chie Hung, M James You, Yutong Sun, Li Ma
Aifu Lin, Chunlai Li, Zhen Xing, Qingsong Hu, Ke Liang, Leng Han, Cheng Wang, David H Hawke, Shouyu Wang, Yanyan Zhang, Yongkun Wei, Guolin Ma, Peter K Park, Jianwei Zhou, Yan Zhou, Zhibin Hu, Yubin Zhou, Jeffery R Marks, Han Liang, Mien-Chie Hung, Chunru Lin, Liuqing Yang
Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng, Zhongqi Ge, Zachary D Nagel, Jun Zou, Chen Wang, Prabodh Kapoor, Xiangyi Ma, Ding Ma, Jiyong Liang, Shumei Song, Jinsong Liu, Leona D Samson, Jaffer A Ajani, Guo-Min Li, Han Liang, Xuetong Shen, Gordon B Mills, Guang Peng
Yuan Yuan, Young Seok Ju, Youngwook Kim, Jun Li, Yumeng Wang, Christopher J Yoon, Yang Yang, Inigo Martincorena, Chad J Creighton, John N Weinstein, Yanxun Xu, Leng Han, Hyung-Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J Campbell, Han Liang, PCAWG Consortium