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John Jumper’s indexed work centers on revolutionizing protein structure prediction through deep learning. As first author of the landmark 2021 *Nature* paper introducing AlphaFold, he demonstrated that a neural network could predict protein structures to near-atomic accuracy, a breakthrough that has accumulated over 46,000 citations. He subsequently led the development of AlphaFold 3, described in a 2024 *Nature* paper as last/senior author, which extended the system to accurately model biomolecular interactions, amassing over 15,000 citations. His earlier first-author work on trajectory-based training for protein simulations and accurate side chain packing calculations laid computational groundwork for these later advances. Beyond his lead-author contributions, Jumper was a key collaborator on several high-impact consortium efforts, including the AlphaFold Protein Structure Database and AlphaFold-Multimer for protein complex prediction, both of which have been cited thousands of times. He also contributed to AlphaMissense, a deep-learning method for predicting missense variant effects across the human proteome. Across these works, Jumper’s research arc demonstrates a sustained focus on bridging machine learning and biophysics to solve fundamental problems in structural biology, from single-protein folding to large-scale genomic interpretation.
John Jumper, Richard Evans, Alexander Pritzel, Tim Green, Michael Figurnov, Olaf Ronneberger, Kathryn Tunyasuvunakool, Russ Bates, Augustin Žídek, Anna Potapenko, Alex Bridgland, Clemens Meyer, Simon A A Kohl, Andrew J Ballard, Andrew Cowie, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Jonas Adler, Trevor Back, Stig Petersen, David Reiman, Ellen Clancy, Michal Zielinski, Martin Steinegger, Michalina Pacholska, Tamas Berghammer, Sebastian Bodenstein, David Silver, Oriol Vinyals, Andrew W Senior, Koray Kavukcuoglu, Pushmeet Kohli
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Josh Abramson, Jonas Adler, Jack Dunger, Richard Evans, Tim Green, Alexander Pritzel, Olaf Ronneberger, Lindsay Willmore, Andrew J Ballard, Joshua Bambrick, Sebastian W Bodenstein, David A Evans, Chia-Chun Hung, Michael O'Neill, David Reiman, Kathryn Tunyasuvunakool, Zachary Wu, Akvilė Žemgulytė, Eirini Arvaniti, Charles Beattie, Ottavia Bertolli, Alex Bridgland, Alexey Cherepanov, Miles Congreve, Alexander I Cowen-Rivers, Andrew Cowie, Michael Figurnov, Fabian B Fuchs, Hannah Gladman, Rishub Jain, Yousuf A Khan, Caroline M R Low, Kuba Perlin, Anna Potapenko, Pascal Savy, Sukhdeep Singh, Adrian Stecula, Ashok Thillaisundaram, Catherine Tong, Sergei Yakneen, Ellen D Zhong, Michal Zielinski, Augustin Žídek, Victor Bapst, Pushmeet Kohli, Max Jaderberg, Demis Hassabis, John M Jumper
Richard Evans, M. E. O’Neill, Alexander Pritzel, Н. В. Антропова, Andrew Senior, Tim Green, Augustin Žídek, Russ Bates, Sam Blackwell, Jason Yim, Olaf Ronneberger, Sebastian W. Bodenstein, Michał Zieliński, Alex Bridgland, Anna Potapenko, Andrew Cowie, Kathryn Tunyasuvunakool, Rishub Jain, Ellen Clancy, Pushmeet Kohli, John Jumper, Demis Hassabis
Kathryn Tunyasuvunakool, Jonas Adler, Zachary Wu, Tim Green, Michal Zielinski, Augustin Žídek, Alex Bridgland, Andrew Cowie, Clemens Meyer, Agata Laydon, Sameer Velankar, Gerard J Kleywegt, Alex Bateman, Richard Evans, Alexander Pritzel, Michael Figurnov, Olaf Ronneberger, Russ Bates, Simon A A Kohl, Anna Potapenko, Andrew J Ballard, Bernardino Romera-Paredes, Stanislav Nikolov, Rishub Jain, Ellen Clancy, David Reiman, Stig Petersen, Andrew W Senior, Koray Kavukcuoglu, Ewan Birney, Pushmeet Kohli, John Jumper, Demis Hassabis
Jun Cheng, Guido Novati, Joshua Pan, Clare Bycroft, Akvilė Žemgulytė, Taylor Applebaum, Alexander Pritzel, Lai Hong Wong, Michal Zielinski, Tobias Sargeant, Rosalia G Schneider, Andrew W Senior, John Jumper, Demis Hassabis, Pushmeet Kohli, Žiga Avsec