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Victor Ambros’s indexed work centers on the discovery and functional characterization of **microRNAs as regulators of developmental timing in *C. elegans*. His landmark senior-author study identified the *lin-4* gene encoding small RNAs with antisense complementarity to *lin-14*, a finding that established a new paradigm for post-transcriptional gene regulation and has accumulated over 12,900 citations. He further delineated the mechanism by which the *lin-4* regulatory RNA blocks LIN-14 protein synthesis after translation initiation, and co-authored a comprehensive review on the functions of animal microRNAs that has been cited more than 10,800 times. His early work also includes a method for efficient gene transfer and extrachromosomal maintenance in *C. elegans*, which became a foundational tool for the field. Beyond these lead-author contributions, Ambros contributed to the systematic annotation of the microRNA family, proposing a uniform system for microRNA annotation and surveying the broad roles of microRNAs in plant and animal development. His expression profiling work uncovered a subset of brain-expressed microRNAs with potential roles in neuronal differentiation** in mammals. Across these studies, his research has consistently illuminated how small non-coding RNAs govern gene expression networks, from the initial discovery of *lin-4* to the elucidation of microRNA pathways in diverse organisms.
R C Lee, R L Feinbaum, V Ambros
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C C Mello, J M Kramer, D Stinchcomb, V Ambros
Victor Ambros, Bonnie Bartel, David P Bartel, Christopher B Burge, James C Carrington, Xuemei Chen, Gideon Dreyfuss, Sean R Eddy, Sam Griffiths-Jones, Mhairi Marshall, Marjori Matzke, Gary Ruvkun, Thomas Tuschl