William C. Hahn

William C. Hahn’s indexed work centers on systematically identifying genetic dependencies in cancer and defining the molecular circuitry that drives tumorigenesis. As senior author, he led the discovery that oncogenic KRAS-driven cancers require TBK1 through systematic RNA interference, a finding with over 4,300 citations. He also spearheaded the Cancer Dependency Map, a large-scale effort published in *Cell* that catalogued essential genes across hundreds of cancer models. Earlier in his career, as first author, he demonstrated that creation of human tumour cells with defined genetic elements is possible, a foundational study that has been cited more than 2,300 times, and showed that inhibition of telomerase limits the growth of human cancer cells. Beyond his lead-author contributions, Hahn contributed to several high-impact collaborative efforts, including the next-generation characterization of the Cancer Cell Line Encyclopedia and the identification of BET bromodomain inhibition as a therapeutic strategy to target c-Myc