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André L. Samson
Inflammation Division, Walter and Eliza Hall Institute of Medical Research
Monash University
André L. Samson’s indexed work centers on the molecular mechanisms of cell death and protease activity, with a particular emphasis on necroptosis and fibrinolysis. His research characterizes how MLKL trafficking and accumulation at the plasma membrane dictate the kinetics of necroptotic cell death, a finding cited in over 350 publications. Earlier lead-author contributions explored the neurological roles of proteases, specifically identifying tissue-type plasminogen activator as a modulator of neurotransmission and synaptic plasticity. This line of inquiry extended to the discovery that this activator requires specific co-receptors to enhance NMDA receptor function. His outputs also include the development of MouseMove, an open-source program for semi-automated movement analysis, which facilitates cognitive testing in rodent models. Publicly indexed outputs suggest a broader involvement in high-impact studies concerning neurodegeneration and inflammatory signaling. He contributed to research identifying how TDP-43 triggers mitochondrial DNA release to activate cGAS/STING, a mechanism with significant implications for ALS. Other collaborative work has examined how sublethal necroptosis signaling promotes inflammation and liver cancer, further bridging the gap between basic cell death pathways and disease progression. Collectively, these works reflect a research arc dedicated to defining the precise spatial and temporal regulation of cellular injury responses, ranging from intracellular protein aggregation to systemic inflammatory outcomes in cancer and neurodegeneration.
Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas, James B Hilton, Michael J Mlodzianoski, Pawat Laohamonthonkul, Cynthia Louis, Ronnie Ren Jie Low, Jonas Moecking, Dominic De Nardo, Katherine R Balka, Dale J Calleja, Fiona Moghaddas, Erya Ni, Catriona A McLean, Andre L Samson, Shiraz Tyebji, Christopher J Tonkin, Christopher R Bye, Bradley J Turner, Genevieve Pepin, Michael P Gantier, Kelly L Rogers, Kate McArthur, Peter J Crouch, Seth L Masters
Andre L Samson, Ying Zhang, Niall D Geoghegan, Xavier J Gavin, Katherine A Davies, Michael J Mlodzianoski, Lachlan W Whitehead, Daniel Frank, Sarah E Garnish, Cheree Fitzgibbon, Anne Hempel, Samuel N Young, Annette V Jacobsen, Wayne Cawthorne, Emma J Petrie, Maree C Faux, Kristy Shield-Artin, Najoua Lalaoui, Joanne M Hildebrand, John Silke, Kelly L Rogers, Guillaume Lessene, Edwin D Hawkins, James M Murphy
Hui San Chin, Mark X Li, Iris K L Tan, Robert L Ninnis, Boris Reljic, Kristen Scicluna, Laura F Dagley, Jarrod J Sandow, Gemma L Kelly, Andre L Samson, Stephane Chappaz, Seong L Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M Hall, Andrew J Kueh, Michael T Ryan, Ruth M Kluck, Philippe Bouillet, Marco J Herold, Daniel H D Gray, David C S Huang, Mark F van Delft, Grant Dewson
Andre L Samson, Robert L Medcalf
Taide Wang, Doris Tomas, Nirma D Perera, Brittany Cuic, Sophia Luikinga, Aida Viden, Samantha K Barton, Catriona A McLean, André L Samson, Adam Southon, Ashley I Bush, James M Murphy, Bradley J Turner
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