Kent State University
Manabu Kurokawa conducts research primarily focused on the molecular mechanisms of cell death and metabolic adaptation in oncology. Publicly indexed outputs suggest a significant emphasis on evading apoptosis in cancer, a topic explored in a highly cited 2013 review that characterizes how malignant cells bypass programmed cell death. His work frequently investigates the intersection of signaling pathways, such as the regulatory interplay between caspases and kinases during cellular distress. More recent senior-authored research has shifted toward metabolic signaling, specifically identifying CD36-mediated metabolic rewiring as a key driver of resistance to HER2-targeted therapies in breast cancer. These contributions highlight a sustained inquiry into how biochemical shifts allow cancer cells to survive therapeutic intervention. Beyond oncology, earlier research contributions involve significant work in reproductive biology and calcium signaling. This includes participation in studies identifying the requirement of phospholipase C delta 4 for the acrosome reaction in sperm, as well as investigations into the triggers of calcium oscillations during mammalian fertilization. His portfolio also details the inhibition of apoptosome formation in tyrosine kinase-induced leukemias, illustrating a career-long focus on the phosphorylation events that govern cell fate. Collectively, these works trace an evolution from studying the fundamental triggers of cellular activation in development to the complex regulatory networks that sustain chemoresistance and survival in human cancers.
William W Feng, Owen Wilkins, Scott Bang, Matthew Ung, Jiaqi Li, Jennifer An, Carmen Del Genio, Kaleigh Canfield, James DiRenzo, Wendy Wells, Arti Gaur, R Brooks Robey, Jessie Yanxiang Guo, Ryan L Powles, Christos Sotiriou, Lajos Pusztai, Maria Febbraio, Chao Cheng, William B Kinlaw, Manabu Kurokawa
K Fukami, K Nakao, T Inoue, Y Kataoka, M Kurokawa, R A Fissore, K Nakamura, M Katsuki, K Mikoshiba, N Yoshida, T Takenawa
Rafael A Fissore, Manabu Kurokawa, Jason Knott, Mao Zhang, Jeremy Smyth
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