Ake Tzu-Hui Lu

Research Statement

AI generated · Oct 12, 2026

Ake Tzu-Hui Lu's indexed work centers on DNA methylation clocks and their links to ageing across species and tissues. As first author, he helped develop a universal DNA methylation age measure applicable across mammalian tissues (396 citations) and the second-generation GrimAge mortality predictor (373 citations), extending earlier first-author work on the genetic architecture of epigenetic and neuronal ageing rates in human brain regions. A distinct early thread addressed candidate-gene associations in autism spectrum disorders, including calcium channel gene defects and sex-stratified GWAS approaches. Beyond these lead-author contributions, Lu appears as a middle author on widely cited consortium studies, including a meta-analysis of DNA methylation-based biological age measures predicting time to death and a genome-wide association study identifying 137 loci for methylation biomarkers of aging, the latter reflecting large-scale collaboration with figures such as Steve Horvath. No software, datasets, patents, or grants are indexed beyond his publications. Taken together, the record traces a trajectory from psychiatric genetics toward epigenetic clock methodology and its application to ageing, mortality, and neurodegeneration.

Most Cited Works

Universal DNA methylation age across mammalian tissues

A T Lu, Z Fei, A Haghani, T R Robeck, J A Zoller, C Z Li, R Lowe, Q Yan, J Zhang, H Vu, J Ablaeva, V A Acosta-Rodriguez, D M Adams, J Almunia, A Aloysius, R Ardehali, A Arneson, C S Baker, G Banks, K Belov, N C Bennett, P Black, D T Blumstein, E K Bors, C E Breeze, R T Brooke, J L Brown, G G Carter, A Caulton, J M Cavin, L Chakrabarti, I Chatzistamou, H Chen, K Cheng, P Chiavellini, O W Choi, S M Clarke

Research Areas

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Telomeres, Telomerase, and SenescenceGenetic Associations and EpidemiologyDementia and Cognitive Impairment Resear

Affiliations & Education

Employment

UCLA(US)
Project Scientist · the Division of Geriatrics, Department of Medicine

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DNA methylation networks underlying mammalian traits

Amin Haghani, Caesar Z Li, Todd R Robeck, Joshua Zhang, Ake T Lu, Julia Ablaeva, Victoria A Acosta-Rodríguez, Danielle M Adams, Abdulaziz N Alagaili, Javier Almunia, Ajoy Aloysius, Nabil M S Amor, Reza Ardehali, Adriana Arneson, C Scott Baker, Gareth Banks, Katherine Belov, Nigel C Bennett, Peter Black, Daniel T Blumstein, Eleanor K Bors, Charles E Breeze, Robert T Brooke, Janine L Brown, Gerald Carter, Alex Caulton, Julie M Cavin, Lisa Chakrabarti, Ioulia Chatzistamou, Andreas S Chavez, Hao Chen, Kaiyang Cheng, Priscila Chiavellini, Oi-Wa Choi, Shannon Clarke, Joseph A Cook, Lisa N Cooper, Marie-Laurence Cossette, Joanna Day, Joseph DeYoung, Stacy Dirocco, Christopher Dold, Jonathan L Dunnum, Erin E Ehmke, Candice K Emmons, Stephan Emmrich, Ebru Erbay, Claire Erlacher-Reid, Chris G Faulkes, Zhe Fei, Steven H Ferguson, Carrie J Finno, Jennifer E Flower, Jean-Michel Gaillard, Eva Garde, Livia Gerber, Vadim N Gladyshev, Rodolfo G Goya, Matthew J Grant, Carla B Green, M Bradley Hanson, Daniel W Hart, Martin Haulena, Kelsey Herrick, Andrew N Hogan, Carolyn J Hogg, Timothy A Hore, Taosheng Huang, Juan Carlos Izpisua Belmonte, Anna J Jasinska, Gareth Jones, Eve Jourdain, Olga Kashpur, Harold Katcher, Etsuko Katsumata, Vimala Kaza, Hippokratis Kiaris, Michael S Kobor, Pawel Kordowitzki, William R Koski, Michael Krützen, Soo Bin Kwon, Brenda Larison, Sang-Goo Lee, Marianne Lehmann, Jean-François Lemaître, Andrew J Levine, Xinmin Li, Cun Li, Andrea R Lim, David T S Lin, Dana M Lindemann, Schuyler W Liphardt, Thomas J Little, Nicholas Macoretta, Dewey Maddox, Craig O Matkin, Julie A Mattison, Matthew McClure, June Mergl, Jennifer J Meudt, Gisele A Montano, Khyobeni Mozhui, Jason Munshi-South, William J Murphy, Asieh Naderi, Martina Nagy, Pritika Narayan, Peter W Nathanielsz, Ngoc B Nguyen, Christof Niehrs, Batsaikhan Nyamsuren, Justine K O'Brien, Perrie O'Tierney Ginn, Duncan T Odom, Alexander G Ophir, Steve Osborn, Elaine A Ostrander, Kim M Parsons, Kimberly C Paul, Amy B Pedersen, Matteo Pellegrini, Katharina J Peters, Jessica L Petersen, Darren W Pietersen, Gabriela M Pinho, Jocelyn Plassais, Jesse R Poganik, Natalia A Prado, Pradeep Reddy, Benjamin Rey, Beate R Ritz, Jooke Robbins, Magdalena Rodriguez, Jennifer Russell, Elena Rydkina, Lindsay L Sailer, Adam B Salmon, Akshay Sanghavi, Kyle M Schachtschneider, Dennis Schmitt, Todd Schmitt, Lars Schomacher, Lawrence B Schook, Karen E Sears, Ashley W Seifert, Aaron B A Shafer, Anastasia V Shindyapina, Melanie Simmons, Kavita Singh, Ishani Sinha, Jesse Slone, Russel G Snell, Elham Soltanmohammadi, Matthew L Spangler, Maria Spriggs, Lydia Staggs, Nancy Stedman, Karen J Steinman, Donald T Stewart, Victoria J Sugrue, Balazs Szladovits, Joseph S Takahashi, Masaki Takasugi, Emma C Teeling, Michael J Thompson, Bill Van Bonn, Sonja C Vernes, Diego Villar, Harry V Vinters, Ha Vu, Mary C Wallingford, Nan Wang, Gerald S Wilkinson, Robert W Williams, Qi Yan, Mingjia Yao, Brent G Young, Bohan Zhang, Zhihui Zhang, Yang Zhao, Peng Zhao, Wanding Zhou, Joseph A Zoller, Jason Ernst, Andrei Seluanov, Vera Gorbunova, X William Yang, Ken Raj, Steve Horvath

Science2023

138Citations

Sources