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Aaron M. Newman’s indexed work centers on computational methods for deconvolving cell-type composition and expression from bulk tissue transcriptomes. His most-cited contribution, CIBERSORT, introduced a robust framework for enumerating cell subsets from tissue expression profiles, enabling widespread tumor microenvironment analysis. He subsequently extended this with CIBERSORTx, a method for determining cell type abundance and expression from bulk tissues with digital cytometry, and applied these approaches in an atlas characterizing clinically distinct cell states and ecosystems across human solid tumors. In parallel, Newman developed ultrasensitive methods for quantitating circulating tumor DNA with broad patient coverage, including integrated digital error suppression for improved detection. Newman contributed as a middle author to several high-impact consortia studies, including The Immune Landscape of Cancer and an analysis of the prognostic landscape of genes and infiltrating immune cells across human cancers. His senior-authored work on single-cell transcriptional diversity as a hallmark of developmental potential and on T cell characteristics associated with toxicity to immune checkpoint blockade in melanoma further demonstrates his focus on linking cellular heterogeneity to clinical outcomes. Across these contributions, Newman has advanced both the computational infrastructure for dissecting tissue composition and the translational application of liquid biopsy and single-cell technologies in oncology.
Aaron M Newman, Chih Long Liu, Michael R Green, Andrew J Gentles, Weiguo Feng, Yue Xu, Chuong D Hoang, Maximilian Diehn, Ash A Alizadeh
Aaron M Newman, Chloé B Steen, Chih Long Liu, Andrew J Gentles, Aadel A Chaudhuri, Florian Scherer, Michael S Khodadoust,
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Andrew J Gentles, Aaron M Newman, Chih Long Liu, Scott V Bratman, Weiguo Feng, Dongkyoon Kim, Viswam S Nair, Yue Xu, Amanda Khuong, Chuong D Hoang, Maximilian Diehn, Robert B West, Sylvia K Plevritis, Ash A Alizadeh
Aaron M Newman, Scott V Bratman, Jacqueline To, Jacob F Wynne, Neville C W Eclov, Leslie A Modlin, Chih Long Liu, Joel W Neal, Heather A Wakelee, Robert E Merritt, Joseph B Shrager, Billy W Loo, Ash A Alizadeh, Maximilian Diehn
Gunsagar S Gulati, Shaheen S Sikandar, Daniel J Wesche, Anoop Manjunath, Anjan Bharadwaj, Mark J Berger, Francisco Ilagan, Angera H Kuo, Robert W Hsieh, Shang Cai, Maider Zabala, Ferenc A Scheeren, Neethan A Lobo, Dalong Qian, Feiqiao B Yu, Frederick M Dirbas, Michael F Clarke, Aaron M Newman