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James H. Doroshow’s indexed work centers on the biochemical mechanisms of chemotherapy-induced toxicity and the development of novel therapeutic strategies. His early, highly cited research established a foundation for understanding enzymatic defenses against reactive oxygen metabolites in cardiac tissue, particularly how anthracycline antibiotics trigger oxidative stress. This line of inquiry, including his 1986 study on anthracycline radical formation by NADH dehydrogenase, has garnered over 600 citations for clarifying the metabolic pathways leading to heart damage. More recently, his focus has shifted toward large-scale drug discovery and clinical translation. As senior author, he led the development of the NCI ALMANAC resource for identifying synergistic anticancer drug pairs, a tool that has significantly influenced combinatorial therapy research. Beyond his primary focus on oxidative stress, Dr. Doroshow has contributed to high-impact collaborative studies involving genomic tools and targeted inhibitors. He is a co-author on influential research regarding the trapping of PARP1 and PARP2 by clinical inhibitors, a work with over 2,100 citations that refined the understanding of DNA repair interference. His portfolio also includes significant contributions to the CellMiner web-based suite for exploring NCI-60 cell line patterns, facilitating broader access to pharmacogenomic data. These diverse outputs suggest a career trajectory that moves from fundamental molecular toxicology to the leadership of national resources for precision oncology and drug screening.
Naoko Takebe, Abdul Rafeh Naqash, Geraldine O'Sullivan Coyne, Shivaani Kummar, Khanh Do, Ashley Bruns, Lamin Juwara, Jennifer Zlott, Larry Rubinstein, Richard Piekarz, Elad Sharon, Howard Streicher, Arjun Mittra, Sarah B Miller, Jiuping Ji, Deborah Wilsker, Robert J Kinders, Ralph E Parchment, Li Chen, Ting-Chia Chang, Biswajit Das, Ganesh Mugundu, James H Doroshow, Alice P Chen
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Funda Meric-Bernstam, James M Ford, Peter J O'Dwyer, Geoffrey I Shapiro, Lisa M McShane, Boris Freidlin, Roisin E O'Cearbhaill, Suzanne George, Julia Glade-Bender, Gary H Lyman, James V Tricoli, David Patton, Stanley R Hamilton, Robert J Gray, Douglas S Hawkins, Bhanumati Ramineni, Keith T Flaherty, Petros Grivas, Timothy A Yap, Jordan Berlin, James H Doroshow, Lyndsay N Harris, Jeffrey A Moscow
Joseph A Flores-Toro, Subhashini Jagu, Gregory T Armstrong, David F Arons, Gregory J Aune, Stephen J Chanock, Douglas S Hawkins, Allison Heath, Lee J Helman, Katherine A Janeway, Jason E Levine, Ellyn Miller, Lynne Penberthy, Charles W M Roberts, Eve R Shalley, Jack F Shern, Malcolm A Smith, Louis M Staudt, Samuel L Volchenboum, Jinghui Zhang, Jean Claude Zenklusen, Douglas R Lowy, Norman E Sharpless, Jaime M Guidry Auvil, Anthony R Kerlavage, Brigitte C Widemann, Gregory H Reaman, Warren A Kibbe, James H Doroshow, Childhood Cancer Data Initiative Working Groups
James H Doroshow
Keith T Flaherty, James H Doroshow, Susan Galbraith, Antoni Ribas, Paul G Kluetz, Richard Pazdur, Marc R Theoret