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Adam Pawson's indexed work centers on the molecular pharmacology of reproductive hormones, with a particular focus on gonadotropin-releasing hormone (GnRH) receptors and their signaling mechanisms. His most-cited lead-author work, the 2013 IUPHAR/BPS Guide to PHARMACOLOGY, established an expert-driven knowledgebase of drug targets and ligands that has become a standard reference. His earlier first-author papers dissect receptor behavior, including contrasting internalization kinetics of human and chicken GnRH receptors and the slow, constitutive internalization of mammalian type I receptors. As senior author, he also contributed to work on kisspeptin antagonists in reproductive physiology and on Wnt signaling via β-catenin stabilization in pituitary gonadotropes, reflecting a sustained interest in both receptor trafficking and downstream intracellular pathways. Beyond his lead-author studies, Pawson contributed to the highly cited IUPHAR/BPS Guide to PHARMACOLOGY updates and the Concise Guide series, which catalog G protein-coupled receptors and enzymes for the broader pharmacology community. His middle-author role in these large consortium efforts, including the 2018 and 2016 database releases, underscores his importance in curating pharmacological knowledge. Earlier collaborative work includes the comprehensive 2004 Endocrine Reviews review of GnRH receptors. Across these outputs, the arc of his contribution links detailed mechanistic studies of GnRH receptor function with the construction of widely used community resources that organize drug-target interactions, bridging bench-level receptor biology and large-scale pharmacological data infrastructure.
Simon D Harding, Joanna L Sharman, Elena Faccenda, Chris Southan, Adam J Pawson, Sam Ireland, Alasdair J G Gray, Liam Bruce, Stephen P H Alexander, Stephen Anderton, Clare Bryant, Anthony P Davenport, Christian Doerig, Doriano Fabbro, Francesca Levi-Schaffer, Michael Spedding, Jamie A Davies, NC-IUPHAR
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Christopher Southan, Joanna L Sharman, Helen E Benson, Elena Faccenda, Adam J Pawson, Stephen P H Alexander, O Peter Buneman, Anthony P Davenport, John C McGrath, John A Peters, Michael Spedding, William A Catterall, Doriano Fabbro, Jamie A Davies, NC-IUPHAR
Adam J Pawson, Joanna L Sharman, Helen E Benson, Elena Faccenda, Stephen P H Alexander, O Peter Buneman, Anthony P Davenport, John C McGrath, John A Peters, Christopher Southan, Michael Spedding, Wenyuan Yu, Anthony J Harmar, NC-IUPHAR
Stephen Ph Alexander, Anthony P Davenport, Eamonn Kelly, Neil Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators
Robert P Millar, Zhi-Liang Lu, Adam J Pawson, Colleen A Flanagan, Kevin Morgan, Stuart R Maudsley