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Andrew L. Goodman’s indexed work centers on the molecular mechanisms by which the gut microbiome influences host health, drug metabolism, and microbial ecology. As senior author, he led a landmark study that mapped human microbiome drug metabolism by gut bacteria and their genes, demonstrating how specific microbial enzymes directly modify pharmaceutical compounds. His earlier first-author work established extensive personal human gut microbiota culture collections that could be characterized and manipulated in gnotobiotic mice, providing a foundational platform for functional microbiome research. He also identified genetic determinants needed for a human gut symbiont to establish itself in its habitat, revealing the specific bacterial genes required for colonization and persistence within the mammalian gut. Beyond these lead-author contributions, Goodman has been a key collaborator on highly cited studies examining the long-term stability of the human gut microbiota and the role of immunoglobulin A coating in identifying colitogenic bacteria in inflammatory bowel disease. His research portfolio also includes work on cross-feeding dynamics within the gut microbiome and the mechanisms by which antimicrobial peptide resistance mediates resilience of gut commensals during inflammation. Across these studies, Goodman’s work consistently integrates genetic, ecological, and translational approaches to understand how specific bacterial traits and community interactions shape the microbiome’s impact on human physiology.
S Manfredo Vieira, M Hiltensperger, V Kumar, D Zegarra-Ruiz, C Dehner, N Khan, F R C Costa, E Tiniakou, T Greiling, W Ruff, A Barbieri, C Kriegel, S S Mehta, J R Knight, D Jain, A L Goodman, M A Kriegel
Elizabeth J Culp
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Michael Zimmermann, Maria Zimmermann-Kogadeeva, Rebekka Wegmann, Andrew L Goodman
Amy K Cain, Lars Barquist, Andrew L Goodman, Ian T Paulsen, Julian Parkhill, Tim van Opijnen
Elizabeth L Johnson, Stacey L Heaver, Jillian L Waters, Benjamin I Kim, Alexis Bretin, Andrew L Goodman, Andrew T Gewirtz, Tilla S Worgall, Ruth E Ley