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Bingliang Fang’s indexed work centers on the development of targeted therapies and gene delivery systems for oncology. As a senior author, he has contributed extensively to understanding mechanisms of resistance to TRAIL-induced apoptosis in cancer, a study that has received 694 citations for its insights into programmed cell death. His research frequently explores the therapeutic potential of pro-apoptotic ligands, including the antitumor activity and bystander effects of the TRAIL gene when delivered via viral vectors. Additionally, his laboratory has investigated small-molecule interventions in lung cancer, such as the inhibition of the PI3K/AKT/mTOR axis by auranofin and the selective activity of ibrutinib in EGFR-mutant cells. Beyond his primary focus on apoptosis, publicly indexed outputs suggest significant contributions to collaborative studies on metabolic vulnerabilities. He is a co-author on high-impact research identifying DHODH-mediated ferroptosis defense as a targetable vulnerability and work characterizing the clinical efficacy of ibrutinib in mantle-cell lymphoma. His earlier first-author publications established foundational methods for adenovirus-mediated hepatic gene transfer in disease models. Collectively, these works reflect a research arc that moves from pioneering gene therapy techniques to the identification of precise molecular targets and metabolic pathways that can be exploited to overcome drug resistance in diverse malignancies.
Chuncheng Hao, Li Wang, Shaohua Peng, Mengru Cao, Hongyu Li, Jing Hu, Xiao Huang, Wei Liu, Hui Zhang, Shuhong Wu, Apar Pataer, John V Heymach, Agda Karina Eterovic, Qingxiu Zhang, Kenna R Shaw, Ken Chen, Andrew Futreal, Michael Wang, Wayne Hofstetter, Reza Mehran, David Rice, Jack A Roth, Boris Sepesi, Stephen G Swisher, Ara Vaporciyan, Garrett L Walsh, Faye M Johnson, Bingliang Fang
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Moon Jong Kim, Christopher Cervantes, Youn-Sang Jung, Xiaoshan Zhang, Jie Zhang, Sung Ho Lee, Sohee Jun, Larisa Litovchick, Wenqi Wang, Junjie Chen, Bingliang Fang, Jae-Il Park
Bingliang Fang, Qing H Meng
Yungchang Chen, Ran Zhang, Li Wang, Arlene M Correa, Apar Pataer, Yi Xu, Xiaoshan Zhang, Chenghui Ren, Shuhong Wu, Qing H Meng, Junya Fujimoto, Vanessa B Jensen, Mara B Antonoff, Wayne L Hofstetter, Reza J Mehran, George Pisimisis, David C Rice, Boris Sepesi, Ara A Vaporciyan, Garrett L Walsh, Stephen G Swisher, Jack A Roth, John V Heymach, Bingliang Fang
Masanori Kawakami, Lisa Maria Mustachio, Yulong Chen, Zibo Chen, Xiuxia Liu, Cheng-Hsin Wei, Jason Roszik, Adam S Kittai, Alexey V Danilov, Xiaoshan Zhang, Bingliang Fang, Jing Wang, John V Heymach, Liliya Tyutyunyk-Massey, Sarah J Freemantle, Jonathan M Kurie, Xi Liu, Ethan Dmitrovsky