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Aaron Ring’s indexed work centers on immune regulation and autoimmunity, with a particular focus on the roles of cytokines, checkpoint receptors, and autoantibodies in disease. As senior author, he led the discovery of diverse functional autoantibodies in patients with COVID-19, a highly cited 2021 *Nature* study that linked autoantibody profiles to disease severity. His earlier first-author work on the adrenaline-activated structure of the β2-adrenoceptor stabilized by an engineered nanobody (2013, *Nature*) provided a foundational structural biology tool. Ring also spearheaded the characterization of IL-18BP as a secreted immune checkpoint that limits IL-18 immunotherapy (2020, *Nature*), and engineered high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging (2015, *PNAS*), demonstrating a sustained focus on translating molecular insights into therapeutic strategies. Beyond his lead-author contributions, Ring has been a key collaborator on several high-impact studies, including work on PD-1 expression by tumour-associated macrophages inhibiting phagocytosis (2017, *Nature*), and sex differences in immune responses underlying COVID-19 outcomes (2020, *Nature*). He also contributed to the development of a yeast surface display platform for rapid discovery of conformationally selective nanobodies (2018, *Nature Structural & Molecular Biology*). Across these efforts, Ring’s research consistently bridges structural immunology, cytokine biology, and autoantibody discovery to inform both fundamental mechanisms and clinical applications in immunotherapy and infectious disease.
Sydney R Gordon, Roy L Maute, Ben W Dulken, Gregor Hutter, Benson M George, Melissa N McCracken, Rohit Gupta, Jonathan M Tsai, Rahul Sinha, Daniel Corey, Aaron M Ring, Andrew J Connolly, Irving L Weissman
Takehiro Takahashi, Mallory K Ellingson, Patrick Wong, Benjamin Israelow
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Eric Song, Ce Zhang, Benjamin Israelow, Alice Lu-Culligan, Alba Vieites Prado, Sophie Skriabine, Peiwen Lu, Orr-El Weizman, Feimei Liu, Yile Dai, Klara Szigeti-Buck, Yuki Yasumoto, Guilin Wang, Christopher Castaldi, Jaime Heltke, Evelyn Ng, John Wheeler, Mia Madel Alfajaro, Etienne Levavasseur, Benjamin Fontes, Neal G Ravindra, David Van Dijk, Shrikant Mane, Murat Gunel, Aaron Ring, Syed A Jaffar Kazmi, Kai Zhang, Craig B Wilen, Tamas L Horvath, Isabelle Plu, Stephane Haik, Jean-Leon Thomas, Angeliki Louvi, Shelli F Farhadian, Anita Huttner, Danielle Seilhean, Nicolas Renier, Kaya Bilguvar, Akiko Iwasaki
Eric Y Wang, Tianyang Mao, Jon Klein, Yile Dai, John D Huck, Jillian R Jaycox, Feimei Liu, Ting Zhou, Benjamin Israelow, Patrick Wong, Andreas Coppi, Carolina Lucas, Julio Silva, Ji Eun Oh, Eric Song, Emily S Perotti, Neil S Zheng, Suzanne Fischer, Melissa Campbell, John B Fournier, Anne L Wyllie, Chantal B F Vogels, Isabel M Ott, Chaney C Kalinich, Mary E Petrone, Anne E Watkins, Yale IMPACT Team, Charles Dela Cruz, Shelli F Farhadian, Wade L Schulz, Shuangge Ma, Nathan D Grubaugh, Albert I Ko, Akiko Iwasaki, Aaron M Ring
Andrew C Kruse, Aaron M Ring, Aashish Manglik, Jianxin Hu, Kelly Hu, Katrin Eitel, Harald Hübner, Els Pardon, Celine Valant, Patrick M Sexton, Arthur Christopoulos, Christian C Felder, Peter Gmeiner, Jan Steyaert, William I Weis, K Christopher Garcia, Jürgen Wess, Brian K Kobilka